Renal Function Trajectories in Patients with Prior Improved eGFR Slopes and Risk of Death.

ABSTRACT:

Background

Multiple prior studies demonstrated that patients with early Chronic Kidney Disease (CKD) and positive estimated Glomerular Filtration Rate (eGFR) slopes experience increased risk of death. We sought to characterize patients with positive eGFR slopes, examine the renal function trajectory that follows the time period where positive slope is observed, and examine the association between different trajectories and risk of death.

Methods and findings

We built a cohort of 204,132 United States veterans with early CKD stage 3; eGFR slopes were defined based on Bayesian mixed-effects models using outpatient eGFR measurements between October 1999 and September 2004; to build renal function trajectories, patients were followed longitudinally thereafter (from October 2004)

SUBMITTER: Xie Y 

PROVIDER: S-EPMC4762675 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature