Impact of ventricular ectopic burden in a premature ventricular contraction-induced cardiomyopathy animal model.

ABSTRACT:

Background

Frequent premature ventricular contractions (PVCs) have been associated with PVC-induced cardiomyopathy (CM) in some patients.

Objective

The purpose of this study was to understand the cardiac consequences of different PVC burdens and the minimum burden required to induce left ventricular (LV) dysfunction.

Methods

Right ventricular apical PVCs at a coupling interval of 240 ms were introduced at different PVC burdens in 9 mongrel canines. A stepwise increase in PVC burden was implemented every 8 weeks from 0% (baseline), 7%, 14%, 25%, 33% to 50% using our premature pacing algorithm. Echocardiogram and 24-hour Holter were obtained at 4- and 8-week period for each PVC burden with a single blinded reader assessing all echocardiographic parameters including thos

SUBMITTER: Tan AY 

PROVIDER: S-EPMC4762722 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature