Ontology highlight
ABSTRACT:
SUBMITTER: Ascensao JA
PROVIDER: S-EPMC4762938 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Ascensao Joao A JA Datta Pratik P Hancioglu Baris B Sontag Eduardo E Gennaro Maria L ML Igoshin Oleg A OA
PLoS computational biology 20160222 2
Understanding how dynamical responses of biological networks are constrained by underlying network topology is one of the fundamental goals of systems biology. Here we employ monotone systems theory to formulate a theorem stating necessary conditions for non-monotonic time-response of a biochemical network to a monotonic stimulus. We apply this theorem to analyze the non-monotonic dynamics of the σB-regulated glyoxylate shunt gene expression in Mycobacterium tuberculosis cells exposed to hypoxia ...[more]