Effects of vitamin D binding protein phenotypes and vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D.

ABSTRACT:

Objective

To determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated free 25(OH)D with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation.

Design, patients and interventions

A randomized controlled trial with 20 000 IU of vitamin D3 per week or placebo for 12 months was designed. A total of 472 subjects, 236 in each of the intervention groups, were included in the analyses.

Main outcome measures

Baseline serum concentrations and increases in serum total 25(OH)D, directly measured free 25(OH)D, calculated free 25(OH)D and DBP.

Results

Serum total 25(OH)D and DBP concentrations were significantly lower in subjec

SUBMITTER: Sollid ST 

PROVIDER: S-EPMC4763092 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature