Population structure and acquisition of the vanB resistance determinant in German clinical isolates of Enterococcus faecium ST192.

ABSTRACT: In the context of the global action plan to reduce the dissemination of antibiotic resistances it is of utmost importance to understand the population structure of resistant endemic bacterial lineages and to elucidate how bacteria acquire certain resistance determinants. Vancomycin resistant enterococci represent one such example of a prominent nosocomial pathogen on which nation-wide population analyses on prevalent lineages are scarce and data on how the bacteria acquire resistance, especially of the vanB genotype, are still under debate. With respect to Germany, an increased prevalence of VRE was noted in recent years. Here, invasive infections caused by sequence type ST192 VRE are often associated with the vanB-type resistance determinant. Hence, we analyzed 49 vanB-positive and vanB-n

SUBMITTER: Bender JK 

PROVIDER: S-EPMC4763178 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature