MR-Guided Near-Infrared Spectral Tomography Increases Diagnostic Performance of Breast MRI.

ABSTRACT:

Purpose

The purpose of this study was to determine the diagnostically most important molecular biomarkers quantified by magnetic resonance-guided (MR) near-infrared spectral tomography (NIRST) that distinguish malignant breast lesions from benign abnormalities when combined with outcomes from clinical breast MRI.

Experimental design

The study was HIPAA compliant and approved by the Dartmouth Institutional Review Board, the NIH, the United States State Department, and Xijing Hospital. MR-guided NIRST evaluated hemoglobin, water, and lipid content in regions of interest defined by concurrent dynamic contrast-enhanced MRI (DCE-MRI) in the breast. MRI plus NIRST was performed in 44 subjects (median age, 46, age range, 20-81 years), 28 of whom had subsequent malignant pathologic

SUBMITTER: Mastanduno MA 

PROVIDER: S-EPMC4763338 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature