Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity.

ABSTRACT:

Study objectives

Narcolepsy with cataplexy is tightly associated with the HLA class II allele DQB1*06:02. Evidence indicates a complex contribution of HLA class II genes to narcolepsy susceptibility with a recent independent association with HLA-DPB1. The cause of narcolepsy is supposed be an autoimmune attack against hypocretin-producing neurons. Despite the strong association with HLA class II, there is no evidence for CD4+ T-cell-mediated mechanism in narcolepsy. Since neurons express class I and not class II molecules, the final effector immune cells involved might include class I-restricted CD8+ T-cells.

Methods

HLA class I (A, B, and C) and II (DQB1) genotypes were analyzed in 944 European narcolepsy with cataplexy patients and in 4,043 control subjects matched by coun

SUBMITTER: Tafti M 

PROVIDER: S-EPMC4763366 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature