Blood Group Antigens C, Lub and P1 May Have a Role in HIV Infection in Africans.

ABSTRACT:

Background

Botswana is among the world's countries with the highest rates of HIV infection. It is not known whether or not this susceptibility to infection is due to genetic factors in the population. Accumulating evidence, however, points to the role of erythrocytes as potential mediators of infection. We therefore sought to establish the role, if any, of some erythrocyte antigens in HIV infection in a cross-section of the population.

Methods

348 (346 HIV-negative and 2 HIV-positive) samples were obtained from the National Blood Transfusion Service as residual samples, while 194 HIV-positive samples were obtained from the Botswana-Harvard HIV Reference Laboratory. Samples were grouped for twenty three antigens. Chi-square or Fischer Exact analyses were used to compare the f

SUBMITTER: Motswaledi MS 

PROVIDER: S-EPMC4764295 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature