Pharmacology of the Adenosine A3 Receptor in the Vasculature and Essential Hypertension.

ABSTRACT:

Background

Essential hypertension is considered to be a multifactorial disorder and its aetiology has yet to be clearly identified. As the adenosine receptors have a significant role in mediating vasodilation, alterations in their structures or signalling pathways may be involved in the development of hypertension. This study aimed to measure the expression of adenosine A3 receptors in a range of cardiovascular tissues and determine whether they could be altered with essential hypertension, and to functionally test responses to adenosine A3 receptor agonists in coronary blood vessels using the isolated perfused heart preparation.

Methods

mRNA samples from cardiovascular tissues and a range of blood vessels were collected from 10 week old male spontaneously hypertensive rats

SUBMITTER: Ho MF 

PROVIDER: S-EPMC4764345 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature