Fornix deep brain stimulation circuit effect is dependent on major excitatory transmission via the nucleus accumbens.

ABSTRACT:

Introduction

Deep brain stimulation (DBS) is a circuit-based treatment shown to relieve symptoms from multiple neurologic and neuropsychiatric disorders. In order to treat the memory deficit associated with Alzheimer's disease (AD), several clinical trials have tested the efficacy of DBS near the fornix. Early results from these studies indicated that patients who received fornix DBS experienced an improvement in memory and quality of life, yet the mechanisms behind this effect remain controversial. It is known that transmission between the medial limbic and corticolimbic circuits plays an integral role in declarative memory, and dysfunction at the circuit level results in various forms of dementia, including AD. Here, we aimed to determine the potential underlying mechanism of for

SUBMITTER: Ross EK 

PROVIDER: S-EPMC4764383 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature