Radiation sparing of cerebral cortex in brain tumor patients using quantitative neuroimaging.

ABSTRACT:

Background and purpose

Neurocognitive decline in brain tumor patients treated with radiotherapy (RT) may be linked to cortical atrophy. We developed models to determine radiation treatment-planning objectives for cortex, which were tested on a sample population to identify the dosimetric cost of cortical sparing.

Material and methods

The relationship between the probability of cortical atrophy in fifteen high-grade glioma patients at 1-year post-RT and radiation dose was fit using logistic mixed effects modeling. Cortical sparing was implemented using two strategies: region-specific sparing using model parameters, and non-specific sparing of all normal brain tissue.

Results

A dose threshold of 28.6 Gy was found to result in a 20% probability of severe atrophy. Average

SUBMITTER: Karunamuni RA 

PROVIDER: S-EPMC4764402 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature