Evidence for a common evolutionary rate in metazoan transcriptional networks.

ABSTRACT: Genome sequences diverge more rapidly in mammals than in other animal lineages, such as birds or insects. However, the effect of this rapid divergence on transcriptional evolution remains unclear. Recent reports have indicated a faster divergence of transcription factor binding in mammals than in insects, but others found the reverse for mRNA expression. Here, we show that these conflicting interpretations resulted from differing methodologies. We performed an integrated analysis of transcriptional network evolution by examining mRNA expression, transcription factor binding and cis-regulatory motifs across >25 animal species, including mammals, birds and insects. Strikingly, we found that transcriptional networks evolve at a common rate across the three animal lineages. Furthermore, differ

SUBMITTER: Carvunis AR 

PROVIDER: S-EPMC4764585 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature