Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling.

ABSTRACT: Müller glia (MG) are the only glial cell type produced by the neuroepithelial progenitor cells that generate the vertebrate retina. MG are required to maintain retinal homeostasis and support the survival of retinal neurons. Furthermore, in certain vertebrate classes, MG function as adult stem cells, mediating retinal regeneration in response to injury. However, the mechanisms that regulate MG development are poorly understood because there is considerable overlap in gene expression between retinal progenitor cells and differentiated MG. We show that the LIM homeodomain transcription factor Lhx2 is required for the development of MG in the mouse retina. Temporally controlled knock-out studies reveal a requirement for Lhx2 during all stages of MG development, ranging from the proliferation

SUBMITTER: de Melo J 

PROVIDER: S-EPMC4764661 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature