Carbonate-based Janus micromotors moving in ultra-light acidic environment generated by HeLa cells in situ.

ABSTRACT: Novel approaches to develop naturally-induced drug delivery in tumor environments in a deterministic and controlled manner have become of growing interest in recent years. Different polymeric-based microstructures and other biocompatible substances have been studied taking advantage of lactic acidosis phenomena in tumor cells, which decrease the tumor extracellular pH down to 6.8. Micromotors have recently demonstrated a high performance in living systems, revealing autonomous movement in the acidic environment of the stomach or moving inside living cells by using acoustic waves, opening the doors for implementation of such smart microengines into living entities. The need to develop biocompatible motors which are driven by natural fuel sources inherently created in biological systems has

SUBMITTER: Guix M 

PROVIDER: S-EPMC4764847 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature