Ontology highlight
ABSTRACT:
SUBMITTER: Taggart J
PROVIDER: S-EPMC4764878 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160222
Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. Here, we demonstrate that elevated MSI2 expression correlates with poor survival in MDS. Conditional deletion of Msi2 in a mouse model of MDS results in a rapid loss of MDS haematopoietic stem and progenitor cells (HSPCs) and reverses the clinical features of M ...[more]