A curative regimen would decrease HIV prevalence but not HIV incidence unless targeted to an ART-naive population.

ABSTRACT: HIV curative strategies currently under development aim to eradicate latent provirus, or prevent viral replication, progression to AIDS, and transmission. The impact of implementing curative programs on HIV epidemics has not been considered. We developed a mathematical model of heterosexual HIV transmission to evaluate the independent and synergistic impact of ART, HIV prevention interventions and cure on HIV prevalence and incidence. The basic reproduction number was calculated to study the potential for the epidemic to be eliminated. We explored scenarios with and without the assumption that patients enrolled into HIV cure programs need to be on antiretroviral treatment (ART). In our simulations, curative regimes had limited impact on HIV incidence if only ART patients were eligible for

SUBMITTER: Dimitrov DT 

PROVIDER: S-EPMC4764923 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature