Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis.

ABSTRACT:

Background

In frontotemporal dementia (FTD) there is a critical lack in the understanding of biological and molecular mechanisms involved in disease pathogenesis. The heterogeneous genetic features associated with FTD suggest that multiple disease-mechanisms are likely to contribute to the development of this neurodegenerative condition. We here present a systems biology approach with the scope of i) shedding light on the biological processes potentially implicated in the pathogenesis of FTD and ii) identifying novel potential risk factors for FTD. We performed a gene co-expression network analysis of microarray expression data from 101 individuals without neurodegenerative diseases to explore regional-specific co-expression patterns in the frontal and temporal cortices for 12 gene

SUBMITTER: Ferrari R 

PROVIDER: S-EPMC4765225 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature