Association of polymorphisms in angiotensin-converting enzyme gene with gestational diabetes mellitus in Indian women.

ABSTRACT:

Background

Numerous genes have been reported in relation with gestational diabetes mellitus (GDM), but the findings were not consistently replicated across populations, or there have been no detailed studies on them. Previous literatures suggested that, out of all angiotensin converting enzyme (ACE) gene polymorphisms, only ACE insertion/deletion (I/D) gene polymorphism has a strong association with GDM in Asian Indian women.

Aim

This study was devoted to evaluate the association of four single nucleotide polymorphisms (SNPs) ACE A240T, C1237T, G2350A and I/D with GDM and Type 2 diabetes mellitus.

Materials and methods

This study recruited 105 GDM cases, 119 Type 2 diabetes mellitus subjects and 120 controls. PCR-RFLP was used for identifying genotypes of ACE A240T, C

SUBMITTER: Aggarwal P 

PROVIDER: S-EPMC4765272 | biostudies-literature | 2016 Jan-Mar

REPOSITORIES: biostudies-literature