Dose/volume-response relations for rectal morbidity using planned and simulated motion-inclusive dose distributions.

ABSTRACT:

Background and purpose

Many dose-limiting normal tissues in radiotherapy (RT) display considerable internal motion between fractions over a course of treatment, potentially reducing the appropriateness of using planned dose distributions to predict morbidity. Accounting explicitly for rectal motion could improve the predictive power of modelling rectal morbidity. To test this, we simulated the effect of motion in two cohorts.

Materials and methods

The included patients (232 and 159 cases) received RT for prostate cancer to 70 and 74 Gy. Motion-inclusive dose distributions were introduced as simulations of random or systematic motion to the planned dose distributions. Six rectal morbidity endpoints were analysed. A probit model using the QUANTEC recommended parameters was als

SUBMITTER: Thor M 

PROVIDER: S-EPMC4765373 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature