No relation between EFHC2 gene polymorphism and Idiopathic generalized epilepsy.

ABSTRACT:

Background

Idiopathic generalized epilepsy (IGE) is an epilepsy form without an underlying brain lesion or neurological indication or symptom. Recent investigations on the genetic origins of IGE and its subtypes report that certain mutations of various ion and non-ion channels genes in the central nervous system may be associated with IGE.

Purpose

In this study we evaluated the relation between IGE and S430Y polymorphism in EFHC2 gene in a Turkish population.

Material/methods

The study enrolled 96 healthy volunteers (47 male, 49 female), served as controls, and 96 IGE patients (41 male, 55 female), IGE diagnosis was confirmed in the neurology department. DNA extractions were performed. The presence of S430Y polymorphism in the exon 9 of EFHC2 gene were analyzed by Rea

SUBMITTER: Berrin T 

PROVIDER: S-EPMC4765430 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature