Inferring orthologous gene regulatory networks using interspecies data fusion.

ABSTRACT:

Motivation

The ability to jointly learn gene regulatory networks (GRNs) in, or leverage GRNs between related species would allow the vast amount of legacy data obtained in model organisms to inform the GRNs of more complex, or economically or medically relevant counterparts. Examples include transferring information from Arabidopsis thaliana into related crop species for food security purposes, or from mice into humans for medical applications. Here we develop two related Bayesian approaches to network inference that allow GRNs to be jointly inferred in, or leveraged between, several related species: in one framework, network information is directly propagated between species; in the second hierarchical approach, network information is propagated via an unobserved 'hypernetwork'. I

SUBMITTER: Penfold CA 

PROVIDER: S-EPMC4765882 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature