Microfluidic devices with templated regular macroporous structures for HIV viral capture.

ABSTRACT: There is a need to develop inexpensive, portable and easy-to-use devices for viral sample processing for resource-limited settings. Here we offer a solution to efficient virus capture by incorporating macroporous materials with regular structures into microfluidic devices for affinity chromatography. Two-dimensional simulations were first conducted to investigate the effects of two structures, a nanopost array and a spherical pore network, on nanoparticle capture. Then, the two structures were created in polymers by templating anodic aluminum oxide films and 3D close-packed silica particles, respectively. When the microdevices containing functionalized porous materials were tested for human immunodeficiency virus (HIV) isolation, capture efficiencies of 80-99% were achieved under a continu

SUBMITTER: Surawathanawises K 

PROVIDER: S-EPMC4765901 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature