Morphometric analysis of calcification and fibrous layer thickness in carotid endarterectomy tissues.

ABSTRACT:

Background

Advanced atherosclerotic lesions are commonly characterized by the presence of calcification. Several studies indicate that extensive calcification is associated with plaque stability, yet recent studies suggest that calcification morphology and location may adversely affect the mechanical stability of atherosclerotic plaques. The underlying cause of atherosclerotic calcification and the importance of intra-plaque calcium distribution remains poorly understood.

Method

The goal of this study was the characterization of calcification morphology based on histological features in 20 human carotid endarterectomy (CEA) specimens. Representative frozen sections (10μm thick) were cut from the common, bulb, internal and external segments of CEA tissues and stained with von

SUBMITTER: Han RI 

PROVIDER: S-EPMC4765924 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature