Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans.

ABSTRACT: The chromosomes of multicellular animals are organized into a series of topologically independent looped domains. This domain organization is critical for the proper utilization and propagation of the genetic information encoded by the chromosome. A special set of architectural elements, called boundaries or insulators, are responsible both for subdividing the chromatin into discrete domains and for determining the topological organization of these domains. Central to the architectural functions of insulators are homologous and heterologous insulator:insulator pairing interactions. The former (pairing between copies of the same insulator) dictates the process of homolog alignment and pairing in trans, while the latter (pairing between different insulators) defines the topology of looped do

SUBMITTER: Fujioka M 

PROVIDER: S-EPMC4765946 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature