Hepatitis B Virus--Specific and Global T-Cell Dysfunction in Chronic Hepatitis B.

ABSTRACT:

Background & aims

T cells play a critical role in viral infection. We examined whether T-cell effector and regulatory responses can define clinical stages of chronic hepatitis B (CHB).

Methods

We enrolled 200 adults with CHB who participated in the National Institutes of Health-supported Hepatitis B Research Network from 2011 through 2013 and 20 uninfected individuals (controls). Peripheral blood lymphocytes from these subjects were analyzed for T-cell responses (proliferation and production of interferon gamma and interleukin 10) to overlapping hepatitis B virus (HBV) peptides (preS, S, preC, core, and reverse transcriptase), influenza matrix peptides, and lipopolysaccharide. T-cell expression of regulatory markers FOXP3, programmed death-1, and cytotoxic T lymphocyte-assoc

SUBMITTER: Park JJ 

PROVIDER: S-EPMC4766024 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature