Herpesvirus Infections and Childhood Arterial Ischemic Stroke: Results of the VIPS Study.

ABSTRACT:

Background

Epidemiological studies demonstrate that childhood infections, including varicella zoster virus, are associated with an increased risk of arterial ischemic stroke (AIS). Other herpesviruses have been linked to childhood AIS in case reports. We sought to determine whether herpesvirus infections, which are potentially treatable, increase the risk of childhood AIS.

Methods and results

We enrolled 326 centrally confirmed cases of AIS and 115 stroke-free controls with trauma (29 days to 18 years of age) with acute blood samples (≤3 weeks after stroke/trauma); cases had convalescent samples (7-28 days later) when feasible. Samples were tested by commercial enzyme-linked immunosorbent assay kits for immunoglobulin M/immunoglobulin G antibodies to herpes simplex virus 1 a

SUBMITTER: Elkind MS 

PROVIDER: S-EPMC4766042 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature