Dataset Information

Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.

ABSTRACT: We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*13:02 (rs4759997; P=5.02×10(-6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02.

SUBMITTER: Shimada-Sugimoto M

PROVIDER: S-EPMC4766370 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.

Shimada-Sugimoto Mihoko M Otowa Takeshi T Miyagawa Taku T Khor Seik-Soon SS Omae Yosuke Y Toyo-Oka Licht L Sugaya Nagisa N Kawamura Yoshiya Y Umekage Tadashi T Miyashita Akinori A Kuwano Ryozo R Kaiya Hisanobu H Kasai Kiyoto K Tanii Hisashi H Okazaki Yuji Y Tokunaga Katsushi K Sasaki Tsukasa T

Human genome variation 20160225

We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*13:02 (rs4759997; P=5.02×10(-6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02. ...[more]

PMID: 27081567

Dataset Information

Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.

Publications

Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.

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