Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer's disease.

ABSTRACT: Alzheimer's disease is a multifactorial dementia disorder characterized by early amyloid-β, tau deposition, glial activation and neurodegeneration, where the interrelationships between the different pathophysiological events are not yet well characterized. In this study, longitudinal multitracer positron emission tomography imaging of individuals with autosomal dominant or sporadic Alzheimer's disease was used to quantify the changes in regional distribution of brain astrocytosis (tracer (11)C-deuterium-L-deprenyl), fibrillar amyloid-β plaque deposition ((11)C-Pittsburgh compound B), and glucose metabolism ((18)F-fluorodeoxyglucose) from early presymptomatic stages over an extended period to clinical symptoms. The 52 baseline participants comprised autosomal dominant Alzheimer's disease mu

SUBMITTER: Rodriguez-Vieitez E 

PROVIDER: S-EPMC4766380 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature