Macrophage-derived Lipocalin-2 contributes to ischemic resistance mechanisms by protecting from renal injury.

ABSTRACT: Renal ischemia-reperfusion injury triggers an inflammatory response associated to infiltrating macrophages which determines the further outcome of disease. Brown Norway rats are known to show endogenous resistance to ischemia-induced renal damage. By contrast, Sprague Dawley rats exhibit a higher susceptibility to ischemic injury. In order to ascertain cytoprotective mechanisms, we focused on the implication of lipocalin-2 protein in main resistance mechanisms in renal ischemia/reperfusion injury by using adoptive macrophage administration, genetically modified ex vivo either to overexpress or to knockdown lipocalin-2. In vitro experiments with bone marrow-derived macrophages both from Brown Norway rats and from Sprague Dawley rats under hypoxic conditions showed endogenous differences reg

SUBMITTER: Jung M 

PROVIDER: S-EPMC4766505 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature