Histopathological nerve and skeletal muscle changes in rats subjected to persistent insulin-induced hypoglycemia.

ABSTRACT: New insulin analogues with a longer duration of action and a flatter pharmacodynamic profile are developed to improve convenience and safety for diabetic patients. During the nonclinical development of such analogues, safety studies must be conducted in nondiabetic rats, which consequently are rendered chronically hypoglycemic. A rat comparator model using human insulin would be valuable, as it would enable differentiation between effects related to either persistent insulin-induced hypoglycemia (IIH) or a new analogue per se. Such a model could alleviate the need for an in-study-comparator and thereby reduce the number of animals used during development. Thus, the aims of the present study were i) to develop a preclinical animal model of persistent hypoglycemia in rats using human insulin

SUBMITTER: Jensen VF 

PROVIDER: S-EPMC4766526 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature