Assessing the Causality between Blood Pressure and Retinal Vascular Caliber through Mendelian Randomisation.

ABSTRACT: We aimed to determine the association between blood pressure (BP) and retinal vascular caliber changes that were free from confounders and reverse causation by using Mendelian randomisation. A total of 6528 participants from a multi-ethnic cohort (Chinese, Malays, and Indians) in Singapore were included in this study. Retinal arteriolar and venular caliber was measured by a semi-automated computer program. Genotyping was done using Illumina 610-quad chips. Meta-analysis of association between BP, and retinal arteriolar and venular caliber across three ethnic groups was performed both in conventional linear regression and Mendelian randomisation framework with a genetic risk score of BP as an instrumental variable. In multiple linear regression models, each 10 mm Hg increase in systolic BP,

SUBMITTER: Li LJ 

PROVIDER: S-EPMC4766565 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature