Unique PFK regulatory property from some mosquito vectors of disease, and from Drosophila melanogaster.

ABSTRACT:

Background

Arthropod-borne diseases are some of the most rapidly spreading diseases. Reducing the vector population is currently the only effective way to reduce case numbers. Central metabolic pathways are potential targets to control vector populations, but have not been well explored to this aim. The information available on energy metabolism, as a way to control lifespan and dispersion through flight of dipteran vectors, is inadequate.

Methods

Phosphofructokinase (PFK) activity was measured in the presence of both of its substrates, fructose-6-phosphate (F6P) and ATP, as well as some allosteric effectors: Fructose- 2,6 - bisphosphate (F2, 6BP), citrate and AMP. Aedes aegypti phosphofructokinase sequence (AaPFK) was aligned with many other insects and also vertebrate sequ

SUBMITTER: Nunes RD 

PROVIDER: S-EPMC4766633 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature