Evaluation of serum and tissue levels of VAP-1 in colorectal cancer.

ABSTRACT:

Background

The endothelial adhesion molecule, vascular adhesion protein-1 (VAP-1, AOC3) promotes lymphocyte recruitment to tumours, although the contribution that VAP-1 makes to lymphocyte recruitment in human colorectal cancer (CRC) is unknown. VAP-1 exists in circulating soluble form (sVAP-1). A previous study demonstrated elevated sVAP-1 levels in CRC patients. The aim of this study was to confirm this finding and study the differences in tissue VAP-1 expression between CRC and healthy tissues.

Methods

sVAP-1 levels were measured in the serum of 31 patients with CRC and 31 age- and sex-matched controls. Tissue VAP-1 levels were measured by immunohistochemistry, quantitative real-time PCR and Western blotting.

Results

The mean sVAP-1 level ± SD was significantly low

SUBMITTER: Ward ST 

PROVIDER: S-EPMC4766640 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature