Pain management strategies for neuropathic pain in Fabry disease--a systematic review.

ABSTRACT:

Background

Neuropathic pain is one of the key features of (classical) Fabry disease (FD). No randomized clinical trials comparing effectiveness of different pain management strategies have been performed. This review aims to give an overview of existing pain management strategies.

Methods

PubMed and Embase were searched up to September 2014 for relevant articles on treatment of neuropathic pain in FD.

Results

Seven-hundred-thirty-one articles were identified of which 26 were included in the analysis. Studies reported on 55 individuals in total, with group-sizes ranging from 1 to 8. Carbamazepine appeared most beneficial: complete pain relief in 5/25, partial relief in 17/25, and no benefit in 3/25 patients. Phenytoin resulted in complete relief in 1/27, partial relief

SUBMITTER: Schuller Y 

PROVIDER: S-EPMC4766720 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature