Ontology highlight
ABSTRACT:
SUBMITTER: Liu K
PROVIDER: S-EPMC4766986 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Liu Ke K Kunii Naoko N Sakuma Megumi M Yamaki Atsumi A Mizuno Satoru S Sato Mayu M Sakai Hiromichi H Kado Sayaka S Kumagai Kazuo K Kojima Hirotatsu H Okabe Takayoshi T Nagano Tetsuo T Shirai Yasuhito Y Sakane Fumio F
Journal of lipid research 20160114 3
Diacylglycerol kinase (DGK) consists of 10 isozymes. The α-isozyme enhances the proliferation of cancer cells. However, DGKα facilitates the nonresponsive state of immunity known as T-cell anergy; therefore, DGKα enhances malignant traits and suppresses immune surveillance. The aim of this study was to identify a novel small molecule that selectively and potently inhibits DGKα activity. We screened a library containing 9,600 chemical compounds using a newly established high-throughput DGK assay. ...[more]