Chemotherapy increases long-term survival in patients with adult medulloblastoma--a literature-based meta-analysis.

ABSTRACT:

Background

Adult medulloblastoma is a potentially curable malignant entity with an incidence of 0.5-1 per million. Valid data on prognosis, treatment, and demographics are lacking, as most current knowledge stems from retrospective studies. Surgical resection followed by radiotherapy are accepted parts of treatment regimes; however, established prognostic factors and data clarifying the role of chemotherapy are missing.

Methods

We investigated 227 publications from 1969-2013, with 907 identifiable, individual patients being available for meta-analysis. Demographic data, risk stratification, and treatment of these patients were similar to previous cohorts.

Results

The median overall survival (mOS) was 65 months (95% CI: 54.6-75.3) , the 5-year overall survival was 50.9

SUBMITTER: Kocakaya S 

PROVIDER: S-EPMC4767241 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature