Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection.

ABSTRACT:

Background

The optimal sequencing of antiretroviral regimens for the treatment of infection with human immunodeficiency virus type 1 (HIV-1) is unknown. We compared several different antiretroviral treatment strategies.

Methods

This multicenter, randomized, partially double-blind trial used a factorial design to compare pairs of sequential three-drug regimens, starting with a regimen including zidovudine and lamivudine or a regimen including didanosine and stavudine in combination with either nelfinavir or efavirenz. The primary end point was the length of time to the failure of the second three-drug regimen.

Results

A total of 620 subjects who had not previously received antiretroviral therapy were followed for a median of 2.3 years. Starting with a three-drug regime

SUBMITTER: Robbins GK 

PROVIDER: S-EPMC4767257 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature