Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes.

ABSTRACT:

Background

Due to the high cost and low reproducibility of many microarray experiments, it is not surprising to find a limited number of patient samples in each study, and very few common identified marker genes among different studies involving patients with the same disease. Therefore, it is of great interest and challenge to merge data sets from multiple studies to increase the sample size, which may in turn increase the power of statistical inferences. In this study, we combined two lung cancer studies using microarray GeneChip, employed two gene shaving methods and a two-step survival test to identify genes with expression patterns that can distinguish diseased from normal samples, and to indicate patient survival, respectively.

Results

In addition to common data transf

SUBMITTER: Jiang H 

PROVIDER: S-EPMC476733 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature