Ontology highlight
ABSTRACT:
SUBMITTER: Zhu N
PROVIDER: S-EPMC4767347 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20160215 3
Self-renewal is a hallmark of both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs); therefore, the identification of mechanisms that are required for LSC, but not HSC, function could provide therapeutic opportunities that are more effective and less toxic than current treatments. Here, we employed an in vivo shRNA screen and identified jumonji domain-containing protein JMJD1C as an important driver of MLL-AF9 leukemia. Using a conditional mouse model, we showed that loss of JMJD1C ...[more]