New Phosphospecific Antibody Reveals Isoform-Specific Phosphorylation of CPEB3 Protein.

ABSTRACT: Cytoplasmic Polyadenylation Element Binding proteins (CPEBs) are a family of polyadenylation factors interacting with 3'UTRs of mRNA and thereby regulating gene expression. Various functions of CPEBs in development, synaptic plasticity, and cellular senescence have been reported. Four CPEB family members of partially overlapping functions have been described to date, each containing a distinct alternatively spliced region. This region is highly conserved between CPEBs-2-4 and contains a putative phosphorylation consensus, overlapping with the exon seven of CPEB3. We previously found CPEBs-2-4 splice isoforms containing exon seven to be predominantly present in neurons, and the isoform expression pattern to be cell type-specific. Here, focusing on the alternatively spliced region of CPEB3,

SUBMITTER: Kaczmarczyk L 

PROVIDER: S-EPMC4767366 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature