Hormone stimulation of androgen receptor mediates dynamic changes in DNA methylation patterns at regulatory elements.

ABSTRACT: DNA methylation is an epigenetic modification that contributes to stable gene silencing by interfering with the ability of transcriptional regulators to bind to DNA. Recent findings have revealed that hormone stimulation of certain nuclear receptors induces rapid, dynamic changes in DNA methylation patterns alongside transcriptional responses at a subset of target loci, over time. However, the ability of androgen receptor (AR) to dynamically regulate gene transcription is relatively under-studied and its role in the regulation of DNA methylation patterns remains to be elucidated. Here we demonstrate in normal prostate cells that hormone stimulated AR activity results in dynamic changes in the transcription rate and DNA methylation patterns at the AR target genes, TIPARP and SGK1. Time-reso

SUBMITTER: Dhiman VK 

PROVIDER: S-EPMC4767454 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature