Magnitude of risk for nodal metastasis associated with lymphvascular space invasion for endometrial cancer.

ABSTRACT:

Objectives

While lymphvascular space invasion (LVSI) is a risk factor for nodal metastasis in endometrial cancer, the magnitude of risk is poorly described. We examined the risk of nodal metastasis associated with LVSI for various combinations of tumor grade and depth of invasion and examined the effect of LVSI on survival.

Methods

We identified patients with T1A (<50% myoinvasion) and T1B (>50% myoinvasion) endometrioid adenocarcinomas of the endometrium diagnosed between 2010 and 2012 and recorded in the National Cancer Database. The risk of nodal metastasis associated with LVSI stratified by grade and stage is reported. The association of LVSI and survival was examined using Kaplan-Meier analyses and Cox proportional hazards models.

Results

We identified 25,907 pat

SUBMITTER: Jorge S 

PROVIDER: S-EPMC4767542 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature