Distinct modulation of allergic T cell responses by subcutaneous vs. sublingual allergen-specific immunotherapy.

ABSTRACT:

Background

Allergen-specific immunotherapy is the only curative treatment for type I allergy. It can be administered subcutaneously (SCIT) or sublingually (SLIT). The clinical efficacy of these two treatment modalities appears to be similar, but potential differences in the immunological mechanisms involved have not been fully explored.

Objective

To compare changes in the allergen-specific T cell response induced by subcutaneous vs. sublingual administration of allergen-specific immunotherapy (AIT).

Methods

Grass pollen-allergic patients were randomized into groups receiving either SCIT injections or SLIT tablets or neither. PBMCs were tested for Timothy grass (TG)-specific cytokine production by ELISPOT after in vitro expansion with TG-peptide pools. Phenotypic chara

SUBMITTER: Schulten V 

PROVIDER: S-EPMC4767546 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature