Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice.

ABSTRACT:

Objective

Hypercholesterolemia and hypertension are associated with aortic valve stenosis (AVS) in humans. We have examined aortic valve function, structure, and gene expression in hypercholesterolemic/hypertensive mice.

Approach and results

Control, hypertensive, hypercholesterolemic (Apoe(-/-)), and hypercholesterolemic/hypertensive mice were studied. Severe aortic stenosis (echocardiography) occurred only in hypercholesterolemic/hypertensive mice. There was minimal calcification of the aortic valve. Several structural changes were identified at the base of the valve. The intercusp raphe (or seam between leaflets) was longer in hypercholesterolemic/hypertensive mice than in other mice, and collagen fibers at the base of the leaflets were reoriented to form a mesh. In hyper

SUBMITTER: Chu Y 

PROVIDER: S-EPMC4767592 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature