Ontology highlight
ABSTRACT:
SUBMITTER: Drier Y
PROVIDER: S-EPMC4767593 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature genetics 20160201 3
Translocation events are frequent in cancer and may create chimeric fusions or 'regulatory rearrangements' that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in adenoid cystic carcinoma (ACC). Whole-genome sequencing data and chromatin maps highlight distinct chromosomal rearrangements that juxtapose super-enhancers to the MYB locus. Chromosome conformation capture confirms th ...[more]