Effective treatment of HER2-amplified breast cancer by targeting HER3 and β1 integrin.

ABSTRACT: The central role of HER2 as the disease driver and HER3 as its essential partner has made them rational targets for the treatment of HER2-amplifed breast cancers, and there is considerable interest in developing highly effective treatment regimens for this disease that consist of targeted therapies alone. Much of these efforts are focused on dual targeting approaches, particularly dual targeting of the HER2-HER3 tumor driver complex itself, or vertical combinations that target downstream PI3K or Akt in addition to HER2. There is also potential in lateral combinations based on evidence implicating cross-talk with other membrane receptor systems, particularly integrins, and such lateral combinations can potentially involve either HER2 or HER3. We established a preclinical model of targeting

SUBMITTER: Campbell MR 

PROVIDER: S-EPMC4767608 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature