Dietary Intake of One-Carbon Metabolism-Related Nutrients and Pancreatic Cancer Risk: The Singapore Chinese Health Study.

ABSTRACT:

Background

Nutrients involved in one-carbon metabolism are hypothesized to protect against pancreatic cancer development.

Methods

The Singapore Chinese Health Study database was used to prospectively examine the association between intake of one-carbon metabolism-related nutrients and pancreatic cancer risk. Between 1993 and 1998, 63,257 men and women ages 45 to 74 years were enrolled into the cohort. The daily intakes of the following one-carbon metabolism-related nutrients were assessed at enrollment using a 165-item food frequency questionnaire: betaine, choline, folate, and vitamins B2, B6, and B12. Multivariable HRs and 95% confidence intervals (CI) for pancreatic cancer risk associated with dietary intakes of one-carbon metabolism-related nutrients were calculated.

SUBMITTER: Huang JY 

PROVIDER: S-EPMC4767683 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature