Clonidine increases bone resorption in humans.

ABSTRACT:

Summary

Inhibition of sympathetic signaling to bone reduces bone resorption in rodents. In contrast, we show that pharmacological reduction of the sympathetic tone increases bone resorption in humans in vivo. This effect does not appear to be mediated via a direct pharmacological effect on the osteoclast.

Introduction

Inhibition of sympathetic signaling to bone reduces bone resorption in rodents. It is uncertain whether a similar role for the sympathetic nervous system exists in humans. The sympathetic tone can be reduced by clonidine, which acts via alpha-2-adrenergic receptors in the brainstem. Our objective was to determine the effect of clonidine on bone turnover in humans.

Methods

The acute effect of a single oral dose of 0.3 mg clonidine on serum bone turnover m

SUBMITTER: Limonard EJ 

PROVIDER: S-EPMC4767867 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature