Sepsis Patients with First and Second-Hit Infections Show Different Outcomes Depending on the Causative Organism.

ABSTRACT:

Objective

With improving rates of initial survival in severe sepsis, second-hit infections that occur following resolution of the primary insult carry an increasing burden of morbidity. However, despite the clinical relevance of these infections, no data are available on differential outcomes in patients with first and second-hit infections depending on the nature of the causative organism. This study aims to explore any differences in these subgroups.

Design

In a retrospective, observational cohort study, the United Kingdom Intensive Care National Audit & Research Centre (ICNARC) database was used to explore the outcomes of patient with first-hit infections leading to sepsis, and sepsis patients with second-hit infections grouped according to the Gram status of the causativ

SUBMITTER: Morgan MP 

PROVIDER: S-EPMC4767904 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature