Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish.

ABSTRACT: The Adverse Outcome Pathway (AOP) framework represents a valuable conceptual tool to systematically integrate existing toxicological knowledge from a mechanistic perspective to facilitate predictions of chemical-induced effects across species. However, its application for decision-making requires the transition from qualitative to quantitative AOP (qAOP). Here we used a fish model and the synthetic glucocorticoid beclomethasone dipropionate (BDP) to investigate the role of chemical-specific properties, pharmacokinetics, and internal exposure dynamics in the development of qAOPs. We generated a qAOP network based on drug plasma concentrations and focused on immunodepression, skin androgenisation, disruption of gluconeogenesis and reproductive performance. We showed that internal exposure dy

SUBMITTER: Margiotta-Casaluci L 

PROVIDER: S-EPMC4768075 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature